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HUMAN VOLTAGE: HOW ELECTRICITY AFFECTS THE BODY

Without electricity, you wouldn't be reading this article right now. And it's not because your computer wouldn't work. It's because your brain wouldn't work.

Everything we do is controlled and enabled by electrical signals running through our bodies. As we learned in intro physics, everything is made up of atoms, and atoms are made up of protons, neutrons and electrons. Protons have a positive charge, neutrons have a neutral charge, and electrons have a negative charge. When these charges are out of balance, an atom becomes either positively or negatively charged. The switch between one type of charge and the other allows electrons to flow from one atom to another. This flow of electrons, or a negative charge, is what we call electricity. Since our bodies are huge masses of atoms, we can generate electricity

When we talk about the nervous system sending "signals" to the brain, or synapses "firing," or the brain telling our hands to contract around a door handle, what we're talking about is electricity carrying messages between point A and point B. It's sort of like the digitalcable signal carrying 1s and 0s that deliver "Law & Order." Except in our bodies, electrons aren't flowing along a wire; instead, an electrical charge is jumping from one cell to the next until it reaches its destination.


Electricity is a key to survival. Electrical signals are fast. They allow for a nearly instantaneous response to control messages. If our bodies relied entirely on, say, the movement of chemicals to tell our hearts to speed up when something is chasing us, we probably would've died out a long time ago.

Those crucial signals that tell our hearts to speed up when we're in danger come from a mass of cells in our heart called the sinoatrial node, or SA node. It's located in the right atrium, and it controls the rhythm of our heartbeat and the movement of blood from the heart to every other part of our body. It's our body's natural pacemaker, and it uses electrical signals to set the pace (see What determines the rhythm of your heart?). But our pulse isn't the only thing that relies on electrical impulses generated by our cells. Almost all of our cells are capable of generating electricity.

In this article, we'll look at the role of electricity in the body and find out how we generate it in the first place.
The starting point is simple: Right now, any cells in your body that aren't actively sending messages are slightly negatively charged. It gets interesting from there.

Human Voltage

Negativity is the natural resting state of your cells. It's related to a slight imbalance between potassium and sodium ions inside and outside the cell, and this imbalance sets the stage for your electrical capacity.
Your cell membranes practice a trick often referred to as the sodium-potassium gate. It's a very complex mechanism, but the simple explanation of these gates, and how they generate electrical charges, goes like this:

Getting struck by lightning is usually enough to fry your body's electrical system.
At rest, your cells have more potassium ions inside than sodium ions, and there are more sodium ions outside the cell. Potassium ions are negative, so the inside of a cell has a slightly negative charge. Sodium ions are positive, so the area immediately outside the cell membrane is positive. There isn't a strong enough charge difference to generate electricity, though, in this resting state.
When the body needs to send a message from one point to another, it opens the gate. When the membrane gate opens, sodium and potassium ions move freely into and out of the cell. Negatively charged potassium ions leave the cell, attracted to the positivity outside the membrane, and positively charged sodium ions enter it, moving toward the negative charge. The result is a switch in the concentrations of the two types of ions -- and rapid switch in charge. It's kind of like switching between a 1 and 0 -- this flip between positive and negative generates an electrical impulse. This impulse triggers the gate on the next cell to open, creating another charge, and so on. In this way, an electrical impulse moves from a nerve in your stubbed toe to the part of your brain that senses pain.

It's also how the SA node tells your heart muscles to contract, how your eyestell your brain that what they just saw is the word "brain," and how you are comprehending this article at all.
Since everything relies on these electrical signals, any breakdown in your body's electrical system is a real problem. When you get an electric shock, it interrupts the normal operation of the system, sort of like a power surge. A shock at the lightning level can cause your body to stop. The electrical process doesn't work anymore -- it's fried. There are also less dramatic problems, like an SA node misfire that causes a heart palpitation (an extra heartbeat), or a lack of blood flow to the heart that upsets the pacemaker and causes other parts of the heart to start sending out impulses. This is sometimes what causes someone to die from coronary artery disease, or narrowing of the arteries. If the heart is constantly being told to contract, it never gets in a full contraction, and it can't get enough blood to the rest of body, leading to oxygen deprivation and a possible heart attack or stroke.

Blood Battery
Panasonic is looking into using human blood to power electrical devices. It's researching how blood could break down sugars to generate power like it generates energy for the human body. This type of "human battery" could ultimately power nano-devices implanted in the body.

With so much electricity jumping around, it may seem like the body is a really great power source. But could human  beings really power the Matrix? Probably not. A human body can only generate between 10 and 100 millivolts [source: NanoMedicine]. A cathode ray tube requires about 25,000 volts to create a picture on a TV[source: Physics Factbook]. If the machines could gather millions of electric eels, on the other hand, they'd be well juiced up. A single eel can produce in the area of 600 volts [source: Physics Factbook].
For more information on the human body's electrical system and related topics, including Panasonic's human-battery research, look over the links on the next page.

An average adult human body at rest generates around 81 watts.
A human cell generates 1 picowatt of power (1/1,000,000,000,000 watt)
A human brain generates around 14 watts.
A human liver generates around 17 watts.
A human intestine generates around 13 watts.
The entire human skin generates around 1.5 watts.
A heart generates 7 watts.
A person standing still can generate around 128 watts.
A person walking can generate around 163 watts.
Brisk walking can generate around 407 watts.

Our body is in a way a mobile portable microelectric generator. If you wanted to see a graphical representation of electricity in action within the body, just take a look at an electrocardiograph. Every wave is an actual voltage of electricity from the heart, the higher the wave the higher the voltage. For every 10 small boxes upwards or downwards is equal to 1 millivolt. Therefore, 1 small box is equal to 0.1 millivolt.
One trend in the fields of Medicine and Bioelectronics is to harness this electricity within the body as efficiently as possible for the diagnosis, treatment, and monitoring of illnesses. If bioengineers would be able to design nanodevices that can power itself using the human cell as its battery, then we won’t have to worry about batteries. Furthermore, it can practically stay within an individual for many years.

CREATINE: DIETARY SUPPLEMENT


Creatine is a dietary supplement that is often used to improve athletic performance. Excessive use of creatine can strain the kidneys and cause kidney damage. Individuals should follow proper dosing recommendations for creatine and consult a physician prior to taking supplements. Individuals who currently take creatine and have kidney problems should discontinue use of creatine to prevent further kidney damage.

Creatine

Creatine is an amino acid that is synthesized in the kidneys and liver and supports muscle growth and contraction, according to Peace Health. Creatine is naturally available in fish and meat and is also marketed to athletes as a performance-enhancing supplement. According to the Mayo Clinic, the most popular creatine supplement is creatine monohydrate. Prolonged use or high doses of creatine may contribute to kidney damage.

Kidneys and Creatinine

Kidneys remove waste from the body, help form red blood cells and help regulate blood pressure. Creatinine is a chemical waste product of creatine. It is usually filtered out through the kidneys and excreted in the urine. High levels of creatinine in the blood can be caused by high doses of creatine and may be a sign of kidney damage and the inability of the kidneys to filter out creatinine.

MedlinePlus says kidney problems that are associated with high creatinine levels include acute tubular necrosis, diabetic nephropathy, glomerulonephritis or pyelonephritis, all of which can lead to chronic kidney disease (CKD) or kidney failure. CKD and kidney failure can result in seizures, coma and, ultimately, death. Individuals with either condition may need dialysis, a regular treatment that cleans the blood, or a kidney transplant.

Lab Values

According to the Mayo Clinic, normal blood creatinine is 0.6 to 1.2 mg/dL. Men usually have higher creatinine levels than women because creatinine increases with muscle mass. High creatinine can be caused by dehydration, certain medications and creatine supplements.

Dosing

The University of Maryland Medical Center says the risk of kidney damage is greater when high doses of creatine supplements are taken. The Mayo Clinic does not advise taking more creatine than is recommended by manufacturers. A normal loading dose for an athlete prior to an athletic event is 5g, four times a day for a week. A maintenance dose for athletes is 2 to 5g per day.

Warnings and Considerations

According to MedlinePlus, possible side effects of creatine supplements include upset stomach, loss of appetite, diarrhea, nausea, muscle cramps, heat intolerance, fever, dehydration, reduced blood volume, electrolyte imbalances, increased thirst, headache, anxiety, irritability, aggression, nervousness, sleepiness, depression, abnormal heart rhythm, fainting or dizziness, blood clots in the legs, seizure and swollen limbs.

Creatine supplements are not regulated by the Food and Drug Administration. Many of the health and performance claims for creatine have not been scientifically substantiated. Peace Health advises that creatine should only be taken after consultation with a doctor or pharmacist. Creatine may not be appropriate for pregnant or breastfeeding women and children. It should not be taken by people with kidney or liver disease due to the risk of further kidney damage and altered liver function.

Creatine and Growth Hormone

  • Creatine, a naturally occurring protein, plays an essential role in muscle development, conversion of fat to energy and possibly brain function and maintenance of the immune system. Importantly for athletes, creatine is reported to enhance physical performance by stimulating the production of human growth hormone (HGH).
    The pituitary gland, a small organ at the base of the brain, produces HGH along with other hormones. HGH regulates muscle development, organ growth and bone length, or height. The pituitary gland continues to produce HGH throughout life, but it releases HGH at slower rates as we age.
    Almost all creatine in the body is concentrated in the muscles, and the remaining 5 percent is found largely in organs with high-energy needs such as the heart, brain and testes. Reduced HGH levels gradually result in typical signs of aging: muscle loss, higher fat-to-muscle ratio and bone loss. Skin sags as it loses elasticity and tone. Illnesses increase as the immune system loses potency.
    HGH supplementation can reverse these signs of aging. However, expense and tight regulation make HGH treatments impractical. Anaerobic exercise, such as weightlifting, or intense, sustained aerobic exercise, such as long-distance running, can boost HGH production. Creatine, obtained either naturally in the diet or through supplements, can also increase HGH.

Effects of Creatine

  • Creatine supplementation stimulates release of HGH from the pituitary, mimicking HGH replacement therapy. Effects of continued creatine supplementation include improved mood, regeneration of bone and muscle mass, reduced body fat and enhanced stamina.
    Because it improves muscle mass and endurance, creatine supplementation is popular among athletes. Other uses of creatine are being explored, such as a treatment for heart disease, muscular dystrophy, Alzheimer's disease and Lou Gehrig's disease.
    Meat, poultry and fish are natural sources of creatine. The liver and kidneys also manufacture creatine using specific amino acids. Additionally, creatine supplements are available in powder or tablet form. Most people receive an average of 2 g of creatine per day in their diet.

Cautions

  • Although creatine is a naturally occurring protein, supplementation is associated with side effects. Creatine supplements are associated with water retention, weight gain, diarrhea, nausea, vomiting, cramping, gastrointestinal problems, muscle pain and high blood pressure.
    Creatine is considered a dietary supplement, not a drug, and is not regulated by the Food and Drug Administration. Quality varies among products, and harmful additives or contaminants are not monitored or controlled.
    Consistent improvement in physical performance has not been proven in scientific research. Some studies have shown creatine supplements slightly boost performance in sports such as weightlifting and sprinting that require short energy bursts. Results vary, however, and not everyone experiences the same level of benefit. Some people don't respond to creatine at all.
    As an untested treatment, creatine supplementation has no standard dose and the long-term risks are unknown. Creatine supplements are not recommended for people with diabetes or kidney or liver disease.

CREATININE LEVEL: SOMETHING TO WATCH OUT FOR

What is creatinine?

Creatinine is a chemical waste molecule that is generated from muscle metabolism. Creatinine is produced from creatine, a molecule of major importance for energy production in muscles. Approximately 2% of the body's creatine is converted to creatinine every day. Creatinine is transported through the bloodstream to the kidneys. The kidneys filter out most of the creatinine and dispose of it in the urine.

Because the muscle mass in the body is relatively constant from day to day, the creatinine level in the blood normally remains essentially unchanged on a daily basis.

Why is it important to check blood creatinine levels?

The kidneys maintain the blood creatinine in a normal range. Creatinine has been found to be a fairly reliable indicator of kidney function.

As the kidneys become impaired for any reason, the creatinine level in the blood will rise due to poor clearance by the kidneys. Abnormally high levels of creatinine thus warn of possible malfunction or failure of the kidneys. It is for this reason that standard blood tests routinely check the amount of creatinine in the blood. A more precise measure of the kidney function can be estimated by calculating how much creatinine is cleared from the body by the kidneys and it is referred to creatinine clearance.

What are "normal" blood creatinine levels?

Normal levels of creatinine in the blood are approximately 0.6 to 1.2 milligrams (mg) per deciliter (dl) in adult males and 0.5 to 1.1 milligrams per deciliter in adult females. (In the metric system, a milligram is a unit of weight equal to one-thousandth of a gram, and a deciliter is a unit of volume equal to one-tenth of a liter.)

Muscular young or middle-aged adults may have more creatinine in their blood than the norm for the general population. Elderly persons, on the other hand, may have less creatinine in their blood than the norm. Infants have normal levels of about 0.2 or more, depending on their muscle development. In people with malnutrition, severe weight loss, and long standing illnesses the muscle mass tends to diminish over time and, therefore, their creatinine level may be lower than expected for their age.

A person with only one kidney may have a normal level of about 1.8 or 1.9. Creatinine levels that reach 2.0 or more in babies and 10.0 or more in adults may indicate severe kidney impairment and the need for a dialysis machine to remove wastes from the blood.

Creatinine Normals

The typical reference ranges are 0.5 to 1.0 mg/dL (about 45-90 μmol/l) for women and 0.7 to 1.2 mg/dL (60-110 μmol/l) for men. While a baseline serum creatinine of 2.0 mg/dL (150 μmol/l) may indicate normal kidney function in a male body builder, a serum creatinine of 0.7 mg/dL (60 μmol/l) can indicate significant renal disease in a frail old woman.

In the United States, creatinine is typically reported in mg/dL, while in Canada and Europe μmol/litre may be used. 1 mg/dL of creatinine is 88.4 μmol/l1.

What are the reasons for elevated blood creatinine?

Any condition that impairs the function of the kidneys will probably raise the creatinine level in the blood. It is important to recognize whether the process leading to kidney dysfunction (kidney failure, azotemia) is longstanding or recent.

The most common causes of longstanding kidney disease in adults are high blood pressure and diabetes mellitus. Certain drugs can sometimes cause abnormally elevated creatinine levels. Serum creatinine can also transiently rise after ingestion of large amount of dietary meat.

Are there any symptoms associated with elevated blood creatinine levels?

The symptoms of kidney dysfunction (renal insufficiency) vary widely. Some people may have a incidental finding of severe kidney disease and elevated creatinine on routine blood work without having any symptoms at all. In others, depending on the cause of problem, many different symptoms may be present including:

  • feeling dehydrated, 
  • fatigue,
  • shortness of breath, 
  • confusion, or 
  • many other nonspecific symptoms.

CREATINE MONOHYDRATE SIDE EFFECTS

Creatine Monohydrate Side Effects

As far as what we've experienced, the best part about creatine is that there are no adverse side effects of creatine. As far as what has been reported in studies, creatine is completely safe and works as a very effective supplement. Yet although there are no risks of taking creatine, we don't know about its long-term effects as the record of research is relatively recent.
Just like every supplement it is not recommended to overuse creatine once your muscles have achieved the saturation value. That is, you should only take the dosage recommended by your doctor or as written on the bottle. A conservative approach is to plan to use creatine only for limited periods before taking a substantial break from it so the body can re-set to normal functioning.

Many experiments performed on creatine have shown that creatine does not cause any adverse side effects as such, but the only effect of taking creatine is that after taking the creatine supplement you will experience an increase in body mass. But, that is the thing I think that all bodybuilders and athletes would love to have.

Creatine Side Effects

In a three-year study designed to find out whether these creatine side effects really do exist, creatine was determined to have no effect on the incidence of injury or cramping in a group of American footballers. Although no negative side effects have ever been noted in the research, some effects that you may physically experience are:
  • Some of the people claim that creatine users are susceptible to cramps, muscle spasms, and some may even be prone to pulled muscles.
  • Persons taking creatine may also show allergic reactions like itching or hives.
  • Sometimes, there may be swelling in your face or hands.
  • Some persons taking creatine said that they had some tingling sensation in their throat.
  • Consumption of creatine may sometimes cause diarrhea or stomach problems.
  • You may sometimes experience trouble in breathing.
  • Creatine in some rare cases may also cause kidney stones.

Other Side Effects of Creatine may be:

  • You may experience chest tightness.
  • You may experience weight gain. But, that from my point of view is not a bad effect; it is a good result as all weight lifters love to have more and more mass.
  • Water Retention.
  • You may notice some gas problems and bloating.
  • Heat Intolerance.
If you are experiencing a lot of adverse side effects you should stop taking creatine right away and talk to your doctor.