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PROSTATE CANCER: how to prevent and cure it

Cancer of the [rpstate os tje second leading cause of cancer death among American men and is the most common carcinoma in men older than age 65. Incidence of prostate cancer is higher in black men, and onset is earlier. The cause of prostate cancer is unknown; there is an increased risk for people with a family history of the disease, and the influence of dietary fat, serum testosterone, vasectomy, and industrial toxins is under investigation. Most prostate cancers are adenocarcinoma and are palpable on rectal examination because they arise from the posterior portion of the gland. Prostate cancer is usually multifocal, slow growing, and can spread by local extension, by lymphatics, or through the bloodstream. Complications include bone metastasis leading to vertebral collapse, spinal cord compression, and pathologic fractures, or spread to urinary tract or pelvic lymph nodes.



Symptoms:


- Pain in lumbosacral area radiating to hips and down legs
- Perineal and rectal discomfort.
- Anemia
- Weight loss
- Nausea
- Oliguria (uremia)
- Hematuria
- Lower extremity edema



What are some of the treatment options for prostate cancer?

The treatment options for prostate cancer depend in part on your age, your overall health and whether the tumor has spread. For tumors that are still inside the prostate, radiation therapy (using a type of X-rays to kill the cancer cells) and a surgery called radical prostatectomy are common treatment options. "Watchful waiting" is also a treatment option. In this approach, no treatment is given until the tumor gets bigger. Watchful waiting may be the best choice for an older man who has a higher risk of dying from something other than his prostate cancer.

Usually, tumors that have grown beyond the edge of the prostate can't be cured with either radiation or surgery. They can be treated with hormones that slow the cancer's growth.

What is radical prostatectomy?

Radical prostatectomy is a surgery to remove the whole prostate gland and the nearby lymph nodes. After the prostate gland is taken out through an incision, a catheter (a narrow rubber tube) is put through the penis into the bladder to carry urine out of the body until the area heals.

Other kinds of prostate surgery are less invasive and have different risks and recovery rates. Your doctor will help decide which type of surgery is the best option for you. Laparoscopic surgery helps the surgeon see inside your body using a thin tube with a tiny camera attached to it. Small cuts are made near the tumor site, and thin tools are used to remove the tumor and surrounding tissue. Some hospitals also have robots to assist in this kind of surgery. The doctor operates the robot arm from a computer.

Your doctor will talk to you about the kind of anesthesia used during surgery. You may be given general anesthesia, which puts you into a sleep-like state. Or an epidural or spinal anesthesia may be given instead. This kind of anesthesia blocks nerve routes from the spine and numbs the area.

What are the risks and benefits of radical prostatectomy?

If you're young and in good health, the short-term risks of this surgery are low. The hospital stay is usually 2 to 3 days, with the catheter left in place for 2 to 3 weeks. You're usually able to go back to work in about 1 month. You shouldn't have severe pain with this surgery. Most men regain bladder control a few weeks to several months after the surgery.

The main advantage of surgery is that it offers the most certain treatment. That is, if all of the cancer is removed during surgery, you are probably cured. Also, the surgery provides your doctor with accurate information about how advanced your cancer is, since the nearby lymph nodes are taken out along with the tumor.

Surgery does have risks. The main risks of radical prostatectomy are incontinence (loss of bladder control) and impotence (loss of the ability to get or keep an erection long enough to have sex). Most bladder and impotence problems improve with time.

Fortunately, only a very low percentage of men have severe incontinence after radical prostatectomy. Up to 35% of men have some accidental leakage of urine during heavy lifting, coughing or laughing. The chance of impotence (erectile dysfunction) is lower if the surgeon is able to avoid cutting the nerves. This may not be possible if the tumor is large. Your age and degree of sexual function before the surgery are also important factors. If you're younger than 50 years of age when you have this surgery, you're likely to regain sexual function. If you're older than 70 years of age, you're more likely to lose sexual function. Remember, even if the nerves are cut, feeling in your penis and orgasms remain normal. Only the ability to get a rigid penis for sexual intercourse is lost. However, there are medicines and devices that can help make the penis rigid.

You could lose a lot of blood during this surgery. Before the surgery, you might want to save about 2 units of your own blood in case you need a transfusion.

What is the purpose of hormone therapy? Are there side effects?

The purpose of hormone therapy is to lower the level of male hormones, called androgens, which are produced mostly in the testicles. Androgens, such as testosterone, help the prostate tumor grow. Shots or pills can be given over a period of several months, or the testicles can be surgically removed. Once the testosterone is out of your body, the prostate cancer usually shrinks and new growth slows down. Hormone treatments are often used in combination with other kinds of prostate cancer treatments.

Hormone therapy does have side effects. Some of the more serious side effects include loss of sex drive, weakened bones, erectile dysfunction, fatigue and osteoporosis.

Hormone treatments are also used in patients who have cancer that has spread beyond the prostate gland. While prostate cancer that has spread usually responds to 1 or 2 years of hormone therapy, it does not cure the disease and most tumors eventually begin to grow again. Once this happens, the treatment goal is to control symptoms. No current treatment can cure prostate cancer once hormone therapy stops working. Recently however, chemotherapy has been shown to help some people who have advanced prostate cancer live longer.

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