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STRUMAZOL: a treatment to Grave's disease

Content: Thiamazole

Indications
Mild to severe hyperthyroidism, treatment of Grave's disease, prep of hyperthyroid patients for thyroidectomy & use as an adjunct to radioactive iodine therapy.

Dosage
Monotherapy Titrate according to hormone levels. Combination therapy w/ thyroid gland hormone replacement Start w/ 30 mg/day. If euthyroidism is involved, add synthetic levothyroxine after approx 6 wk.


Administration
Should be taken with food (Take after meals.).


Contraindications
Proven hypersensitivity to thiamazole & carbimazole; agranulocytosis during previous treatment w/ thiamazole, carbimazole or PTU (in connection w/ the cross-hypersensitivity).

Special Precautions
Pregnancy & lactation.

Adverse Drug Reactions
Fever, arthralgia, arthritis, rashes, leukopenia, agranulocytosis, hepatotoxicity, vasculitis, LE (lupus erythematosus) syndrome, aplastic anemia, thrombocytopenia, nephrotic syndrome, loss of the sense of taste.

Drug Interactions
As Strumazol leads to a change in the metabolism, it may be necessary to adjust the dosage of other drugs.
View more drug interactions with Strumazol
Pregnancy Category (US FDA)

Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

MIMS Class
Antithyroid Agents

ATC Classification
H03BB02 - Thiamazole ; Belongs to the class of sulfur-containing imidazole derivative agents. Used in the management of thyroid diseases.

1 comment:

  1. In other word a totally horrendous drug to take

    ReplyDelete